![]() In view of their defensive function, LTPs are essentially localized in the pericarp of the fruits and they could directly trigger contact reactions in sensitized people. LTPs were originally identified for their ability to catalyze intracellular lipidic exchanges, but it has also been recently proposed that they may have an important defensive role against fungal and bacterial pathogens of plants. For these reasons, sensitization to LTPs is associated with a high risk of systemic reactions, even severe (angioedema, anaphylaxis), following the intake of foods that are contained, either in the form of raw foods, cooked or preserved ones. This structure gives them a high resistance to gastrointestinal proteolysis, to pH and high temperatures. Almost all LTPs belong to the nsLTP1 family ( Lipid transfer proteins are constituted by a stable and compact secondary structure consisting of a hydrophobic cavity able to accommodate ligands surrounded by four α-helices stabilized by highly conserved disulfide bridges. The LTPs are small and soluble proteins characterized by six to eight cysteine residues on the basis of their molecular weight, it is possible to classify them into two classes: nsLTP1 (9 kDa) and nsLTP2 (7 kDa). In this review article, we tried to summarize the current knowledge about this allergy in children population. The sensitization is induced by the oral route and in the LTP allergic patients the clinical manifestations can range from mild symptoms to severe anaphylaxis.Ĭurrently, the LTP allergy is well described in adults, but less is known about the epidemiology and clinical features of this disease in pediatric patients. 4–6 For these reasons, they may determine reactions after oral ingestion of fresh or processed food. LTPs are a family of proteins stable to the heat, gastric digestion and food preservation methods. In contrast, LTP pollen allergens of Parietaria (Par j 1 and Par j 2) and olive (Ole e 7) do not cross-react with allergenic LTPs from plant foods nor between themselves. The wide range of involved foods may be explained by their cross-reactivity between the LTPs present in botanically related and unrelated foods due to their molecular structure similarity. Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. ![]() Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon PublicationsĪllergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood.
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